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Solving a 31-year-old grand challenge in mathematics – the KLS conjecture Nouveau
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Solving a 31-year-old grand challenge in mathematics – the KLS conjecture

For decades, a fundamental question about the difficulty of computing in high-dimensional spaces has resisted proof. New research resolves this question, removing a major theoretical obstacle to understanding the efficiency of randomized algorithms used across science and computing. The Kannan–Lovász–Simonovits (KLS) conjecture was proposed in 1995. It asks whether, for a broad class of high-dimensional […] The post Solving a 31-year-old grand challenge in mathematics – the KLS conjecture…

Microsoft Research
Called to serve: Tech, research, and positive impact Récent
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Called to serve: Tech, research, and positive impact

Lab Director Chris White has worked on research challenges with real-world implications—from new approaches to wartime data analysis to tools for combating human trafficking. He talks to program manager Weishung Liu about the influences that led to the work and more. The post Called to serve: Tech, research, and positive impact appeared first on Microsoft Research.

Microsoft Research
Simulating student learning for better AI tutoring
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Simulating student learning for better AI tutoring

StudentSim is a research system for evaluating and improving AI tutoring tools before they are tested with learners. It models how individuals may engage with tutors, giving feedback to improve tutor performance across subjects like chess, writing, and mathematics. The post Simulating student learning for better AI tutoring appeared first on Microsoft Research.

Microsoft Research
Agent Lightning v1.0: A 3,500-Line Lightweight Agentic RL Framework for Training Agents with Real Harnesses
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Agent Lightning v1.0: A 3,500-Line Lightweight Agentic RL Framework for Training Agents with Real Harnesses

Training AI agents with reinforcement learning can be challenging because their tools, context, and decision-making are managed by complex frameworks. Agent Lightning connects existing agents to RL training, making it easier to improve them without rebuilding them. The post Agent Lightning v1.0: A 3,500-Line Lightweight Agentic RL Framework for Training Agents with Real Harnesses appeared first on Microsoft Research.

Microsoft Research
What AI gets wrong and what failure teaches us
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What AI gets wrong and what failure teaches us

Jennifer Neville did not want to go into computer science—but that’s exactly where she landed. Neville discusses the starts and stops that led to her professional sweet spot and her work identifying “surprising failures” making it hard for AI to handle complexity. The post What AI gets wrong and what failure teaches us appeared first on Microsoft Research.

Microsoft Research
Introducing Quine: An AI research system designed for the complexity of biology
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Introducing Quine: An AI research system designed for the complexity of biology

Biology doesn't operate in silos, and neither should the AI representation of it. Quine is an early-stage research effort to create a multimodal world model of biology. By connecting insights across biological scales and modalities, Quine helps scientists computationally search a space far larger than intuition allows and prioritize hypotheses before they reach the lab. Experimental results provide important feedback, helping researchers sharpen future research directions. The post Introducing…

Microsoft Research
One year in: How Microsoft Research Asia – Singapore is advancing research, partnership and talent for real-world impact
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One year in: How Microsoft Research Asia – Singapore is advancing research, partnership and talent for real-world impact

Since launching a year ago, the Microsoft Research Asia — Singapore lab has established a strong foundation, deepened collaboration across government, academia, and industry, and explored how frontier AI research can create real-world value. The post One year in: How Microsoft Research Asia – Singapore is advancing research, partnership and talent for real-world impact appeared first on Microsoft Research.

Microsoft Research
Offloaded inference for real-world physical AI robotics
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Offloaded inference for real-world physical AI robotics

Robots are getting smarter, but how can their hardware match that growth? New Microsoft Research findings show that moving AI inference beyond the robot can improve task success, boost efficiency, and support more advanced physical AI workloads. The post Offloaded inference for real-world physical AI robotics appeared first on Microsoft Research.

Microsoft Research
Improving synthesis prediction of small molecules at scale with RetroChimera
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Improving synthesis prediction of small molecules at scale with RetroChimera

Custom-made molecules are advancing medicine, materials, and agriculture, but producing them is slow and expensive. A new Nature paper highlights RetroChimera, a predictive model that helps accelerate chemical synthesis, helping researchers explore a wide range of molecules. The post Improving synthesis prediction of small molecules at scale with RetroChimera appeared first on Microsoft Research.

Microsoft Research
GigaPath-Flash and GigaTIME-Flash: Toward population-scale discovery with efficient pathology foundation models
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GigaPath-Flash and GigaTIME-Flash: Toward population-scale discovery with efficient pathology foundation models

What if pathology foundation models could do more with less? GigaPath-Flash and GigaTIME-Flash cut computational demands while maintaining strong performance, opening the door to larger studies and broader exploration. The post GigaPath-Flash and GigaTIME-Flash: Toward population-scale discovery with efficient pathology foundation models appeared first on Microsoft Research.

Microsoft Research
Broadening access to Skala creates a faster path to predictive DFT 
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Broadening access to Skala creates a faster path to predictive DFT 

Skala 1.1, the updated deep-learning exchange-correlation functional from Microsoft Research, provides greater accuracy, expanded accessibility across the computational chemistry ecosystem, and a living benchmark to track computational performance. The post Broadening access to Skala creates a faster path to predictive DFT appeared first on Microsoft Research.

Microsoft Research
Introducing CARE-X: Towards Clinically Useful Radiology VLMs with Auxiliary Supervision, Reward-Aligned Learning, and Tool-Augmented Measurement
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Introducing CARE-X: Towards Clinically Useful Radiology VLMs with Auxiliary Supervision, Reward-Aligned Learning, and Tool-Augmented Measurement

Radiology AI is evolving beyond report generation. CARE-X explores a unified approach that combines flexible reasoning, calibrated predictions, and measurement-based tools for chest X-ray interpretation. The post Introducing CARE-X: Towards Clinically Useful Radiology VLMs with Auxiliary Supervision, Reward-Aligned Learning, and Tool-Augmented Measurement appeared first on Microsoft Research.

Microsoft Research
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